Genetic predisposition to breast cancer
Genetic predisposition to breast cancer: It is estimated that 5-10% of breast cancers are associated with genetic mutations inherited from a person’s mother or father.
Understanding Breast Cancer – 2022
Women often feel that breast cancer is an inevitable part of life. This is not true. Breast cancer can be prevented.
Awareness of breast cancer and the availability of preventive measures are key to reducing the incidence of this disease in women worldwide.
The most important step in prevention and early detection of breast cancer is to follow a healthy lifestyle and get regular health checkups and screenings.
Although breast cancer is considered a “woman-only” disease, men can develop it as well. Breast cancer occurs when a tumor grows in the breast and can be either benign (noncancerous), or malignant (cancerous). Cancer cells may spread to other parts of the body through small vessels in the lymph system called lymphatic vessels.
The causes of breast cancer are unknown, but certain risk factors increase the likelihood of developing it. These include:
Being female – In Western countries, the lifetime risk of developing breast cancer is about 1 in 8; however, this figure could be higher if the woman is at high risk for developing it. Family history – A woman whose mother or sister has had breast cancer is twice as likely to develop it herself than women who have no family history. Age – The risk increases as you get older. Most cases occur in women over 50, but younger women can develop it too. Obesity – Women who are obese have a higher risk of breast cancer than lean women do. This may be due to increased levels of estrogen in obese women. Increased levels of estrogen hormone can cause breast tissue to grow at an accelerated rate which increases the chances of abnormal cell growth that leads to breast cancer.
The causes of breast cancer are not yet fully understood. However, research suggests that some lifestyle factors, such as being overweight or obese, drinking alcohol and not being physically active, may increase the risk of developing the disease.
More than 80% of breast cancers occur in women who have no family history of breast cancer. These occur due to genetic mutations that happen as a result of the aging process and life in general, rather than inherited mutations.
However, having a biological relative with one of these risk factors increases the risk of developing breast cancer.
Genetic predisposition to breast cancer: It is estimated that 5-10% of breast cancers are associated with genetic mutations inherited from a person’s mother or father. The most common gene mutation is BRCA1 on chromosome 17. Other genetic mutations linked to an increased risk include PALB2, ATM and CHEK2, among others.
Women with harmful gene mutations tend to develop breast cancer at an early age (before 40 years). They also have a higher risk of developing both breasts. And ovarian cancer has been reported.
Diet has a profound effect on breast cancer. In particular, there are foods that promote the growth of cancer cells, while others have the opposite effect.
The most common causes of breast cancer are estrogen levels and increased body fat mass. Estrogen is a hormone that plays an important role in the development of the breasts and its fluctuations can easily lead to some diseases such as breast cancer or fibroids in the breast area. Fat mass increases when we eat fatty foods excessively, and increases our chances of getting breast cancer.
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